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M94A2470.TXT
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Document 2470
DOCN M94A2470
TI Follow-up of HIV-1 seronegative female partners of seropositive men in
Brazil.
DT 9412
AU Boschi-Pinto C; Castilho E; Guimaraes MD; Alves LA; Hearst N; FIOCRUZ,
Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):297 (abstract no. PC0116). Unique
Identifier : AIDSLINE ICA10/94370105
AB OBJECTIVES: To assess seroconversion rate of initially seronegative
female partners (FPs) of HIV positive men and to describe potential risk
factors for these seroconverting women such as sexual behavior, lack of
condom use, and history of STDs. METHODS: Sixty-four FPs of HIV positive
men who had been seronegative at baseline were re-tested 6 to 33 months
later (mean of 14.2 months). Two ELISA tests were followed by a
confirmatory Western Blot test (WB). RESULTS: Twelve women showed
evidence of possible new infection. Two women were positive for all
tests (minimum seroconversion rate of 1.8 per 100 person-years). Ten
others had indeterminate WB: 4 were positive for p24, 5 for p55 and p66,
and 1 for p51 (a probable seroconversion rate of 11.0 per 100
person-years). At baseline, all had been negative for all tests.
Questionnaire data were available for 92% of the 64 couples. The mean
length of the relationship was 9.5 years. The mean time since the men
knew they were seropositive was 15.5 months. About 86% of the male
partners were bisexual. Eighteen of the women reported history of STDs
(30.5%); 3 out of the 12 converting women reported anal sex (25%). One
of these three women continued to practice anal sex after learning that
her partner was infected and also reported never using condoms. Four
seroconverting women reported always using condom and 2 reported using
them most of the time during vaginal sex after learning that their
partners were infected. CONCLUSIONS: There is substantial seroconversion
in this cohort of sexual partners of HIV positive men. This seems
largely due to continued high risk sex with their infected partners,
although condom failure cannot be ruled out. Further study of
seroconversion and behavior in these couples will help our understanding
of heterosexual transmission, especially in stable couples, and the
development of effective prevention strategies.
DE Brazil Female Follow-Up Studies Human HIV Infections/*TRANSMISSION
*HIV Seronegativity *HIV Seropositivity *HIV-1 Male Risk Factors
*Sex Behavior Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).